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Extracellular Vesicles

From Concept to Scale: Manufacturing Innovation

As the search for drug delivery vehicles with tissue specificity and immune evasion intensifies, extracellular vesicles (EV) are gaining recognition as a cutting-edge solution.

At Landmark Bio, we excel in optimizing every stage of extracellular vesicle development, from cell line engineering and cargo loading to production and purification. Coupled with our seasoned analytical sciences team we can help advance and manufacture your EV technologies.

Drug Development Services Built for Extracellular Vesicle Therapies

Upstream

  • Cell line and reagent selection: Identification and derisking critical materials including cell lines for exosome production
  • Scalable Production Schemes: Fed batch and continuous perfusion-based technologies

Downstream

  • Broad purification support: Multiple technologies can be integrated into your process such as TFF, SPTFF, ultracentrifugation and diverse chromatography approaches
  • Internal Analytics: For characterization, technology development, in-process testing and lot release testing

Particle Loading

  • Cell-intrinsic and extrinsic solutions: Capacity to support development and manufacture of broad exosome loading strategies

Technology Development

  • Manufacturing partnerships: Innovation in manufacturing technology is a core tenant of Landmark Bio. Contact us to explore the multiple partnership models we offer to co-develop disease agnostic manufacturing technologies
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